EPR Spectroscopic Characterization of Neuronal NO Synthase
نویسندگان
چکیده
منابع مشابه
Normal vascular development in mice deficient in endothelial NO synthase: possible role of neuronal NO synthase.
PURPOSE Nitric oxide formation by nitric oxide synthase (NOS) has been implicated in vascular injury and retinal neovascularization during oxygen-induced retinopathy. However, the role of NOS in normal retinal vascular development and growth has not been studied. The purpose of these experiments was to characterize the expression of NOS in relation to vascular development and to determine the e...
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The nitric oxide synthases (NOSs) are dimeric flavocytochromes consisting of an oxygenase domain with cytochrome P450-like Cys-ligated haem, coupled to a diflavin reductase domain, which is related to cytochrome P450 reductase. The NOSs catalyse the sequential mono-oxygenation of arginine to N-hydroxyarginine and then to citrulline and NO. The constitutive NOS isoforms (cNOSs) are regulated by ...
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Hydroxylamine oxidoreductase (HAO) from the autotrophic nitrifying bacterium Nitrosomonas europaea catalyzes the oxidation of NH2OH to NO2-. The enzyme contains eight hemes per subunit which participate in catalysis and electron transport. NO is found to bind to the enzyme and inhibit electron flow to the acceptor protein, cytochrome c554. NO is found to oxidize either partially or fully reduce...
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Nitric oxide is produced in mammals by a class of enzymes called NO synthases (NOSs). It plays a central role in cellular signalling but also has deleterious effects, as it leads to the production of reactive oxygen and nitrogen species. NO forms a relatively stable adduct with ferrous haem proteins, which, in the case of NOS, is also a key catalytic intermediate. Despite extensive studies on t...
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Thermoresponsive polymeric materials are of great interest owing to their potential use in fields such as actuation, drug delivery, and surface modification. Ever since the discovery by Wu and co-workers of the coil–globule transition of single poly(N-isopropylacrylamide) (PNiPAAm) chains near the lower critical solution temperature (LCST), the collapse mechanism including the formation of stab...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 1996
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi965003w